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Last reviewed: June 16, 2026 Last updated: June 16, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
But unchecked, they may cause issues

Dentin R, Pgorier JP, Benhamed F, Foufelle F, Ferr P, Fauveau V, et al
[16] [17] Whereas the latter directly act on the dopamine transporter (DAT) to inhibit the reuptake and/or induce the release of dopamine, bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase), key enzymes in the dopamine biosynthesis pathway
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There is, however, one nutrient deficiency that is rampant and can lead to problems much more concerning than dark circles
Persons with known hypersensitivity to tirzepatide