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Description
Receptor target
TNF increases phosphorylation of PLIN1 and decreases expression of both PLIN1 and G0S2 (180-182) thereby promoting greater basal lipolysis and release of FAs into plasma
Preclinical models show activity over 48 weeks
This approach is explored with small molecule drug erastin (named after eradicator of RAS and ST-expressing cells) identified to efficiently kill human tumor cells without affecting their isogenic normal cell counterparts [160]
Curcumin has a low absorption rate hence it is important to consume concentrated turmeric extract to improve the absorption of curcumin
PMCID: PMC4094061
