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In a study using a rotenone-induced PD mouse model, combined with antibiotic-induced microbiome depletion and fecal microbiota transplantation, it was found that gut microbiota dysbiosis, along with leaky gut-induced bacterial endotoxins, activates C/EBP/AEP signaling and -syn pathology, ultimately leading to neurodegeneration in PD (52)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Samrat SK, Li W, Singh S, Kumar R, Agrawal B