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It can be further oxidized to N-methyl-2-pyridone-5-carboxamide (2PY) and N-methyl-4-pyridone-3-carboxamide (4PY) in vivo and is easily excreted in urine in the forms of MNA, 2PY, and 4PY (in humans, the major metabolite of MNA is 2PY, and in rodents, the major metabolite of MNA is 4PY) [6567]

Gut microbiota dysbiosis in hyperuricaemia promotes renal injury through the activation of NLRP3 inflammasome

Pietanza MC

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After taking weekly doses for the first four weeks on the medication, patients only have to inject on a monthly basis

Furlan R, Filippi M, Bergami A, Rocca MA, Martinelli V, Poliani PL, et al