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Kirk JA, Raghupathy P, Stevens MM, Cowell CT, Menser MA, Bergin M, Tink A, Vines RH, Silink M

It has been demonstrated that schisandrin B stimulate the expression of Hsp70 in normal cells [95,96,97,98,99,100,101], which is associated with the enhancement of mitochondrial glutathione status [95,97,100,101,102,103], antioxidant activity [59,96,104,105,106,107,108,109], ATP generation [110], mitigation of age-related impairments in mitochondrial antioxidant status and functional ability in various tissues, enhancement in cognitive functions and an increase in the survival of aging in rodents [56,97,112]

Next, an automatic threshold using the Otsu method was applied to establish segmentation boundaries based on intensity distribution
