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Intriguingly, treatment of proteasome inhibitor MG-132 could rescue the decrease in YAP1 protein levels in CDK4/6-depleted cells or cells treated with Abemaciclib, indicating a proteasome-dependent mechanism (Figs

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Winter G, et al

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Similarly, there was reduced GPX1 mRNA in macrophages derived from patients with active CD compared with healthy controls

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