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Ab DPcob showed larger conformational change in the light state compared to that in the dark state indicated by structural deviation (RMSD) from the same starting structure (Supplementary Fig

Full-length human growth hormone represents the central mediator of this axis and is commonly used in research to examine direct growth hormone receptor activation and downstream signaling networks such as JAK2/STAT pathways

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The clinical manifestations are heterogeneous, but they can also differ depending on the grade and duration of the deficiency