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Manipulation with ezrin expression in astrocytes also indicated the resilience of mice to chronic stress: ezrin downregulation increased susceptibility to stress and facilitated emergence of depression-like behaviors, whereas overexpression of ezrin made mice resistant to chronic stress 147

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Furthermore, a statistical futility analysis also suggested that 100 more patients would be inadequate to determine efficacy, therefore the study was discontinued after the first 100 patients

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Curcumin prevents testicular toxicity in rats treated with dexamethasone through the upregulation of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) and improvement of spermatogenic disorders (Khorsandi et al., 2013)