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Valproate free fraction was increased 4-fold in the presence of aspirin compared to valproate alone

It has been shown that carnitine and its acyl derivatives had potential antioxidant effects [20]

This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]

High performance liquid chromatography A LC-ESI-MS/MS system (UPLC, ExionLC AD, MS, QTRAP System, was used to analyze the sample extracts

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Metabolic reprogramming aggravating neuroinflammation post-stroke Lactate accumulation and HIF-1 signaling During ischemic stroke, hypoxia and glucose deprivation compel cells to transition from oxidative phosphorylation to anaerobic glycolysis [115, 133, 134]