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M.Pereira RdeA.da Silva FlixG.de Souza AquinoJ.et al (2016)

Cancer patients treated with Taxanes: Acetyl-L-carnitine might worsen symptoms (Nerve damage in the hands and feet) in some patients using taxanes chemotherapeutic drugs

However, in large doses it interferes with mitochondrial metabolic pathways leading to cellular failure

461 These neurons also demonstrate increased spontaneous activity independent of ascending afferent input and possess enlarged receptive fields, suggesting that thalamic neurons function as central generators or amplifiers of pain in DPN

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Animal studies indicate it limits UVA-induced damage, notably by reducing oxidative stress, inflammation, and DNA alterations