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Additionally, esculetin (20-80 mg/kg) inhibits tBCCAO-induced activation of the mitochondrial apoptosis pathway and autophagy in mice by reducing the expression levels of autophagy-related factors (such as Bnip3, Beclin1, Pink1 and parkin) and apoptosis-related factors (such as p53, Bax and caspase 3) by activating the Nrf2 signaling pathway (43)

Some studies suggest that moderate coffee consumption may actually increase overall antioxidant capacity, including glutathione levels

JAMA Netw Open 2:e1910154
It's a catastrophic point of failure that we see far too often

A.StrathdeeG.SluddenJ.KayeS

Studies exploring molecular mechanisms remain relatively few and it is still not clear how Keap1-NRF2 dissociation is deregulated in NSCs from physiological to pathological conditions such as neuroinflammation