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Multicenter series indicate that 7080% of genetically confirmed patients improve or stabilize on 1060 mg kg 1 day 1 , with greater benefit when therapy starts within 12 months of symptom onset (20)

6 They also develop non-Hodgkin lymphoma (NHL) more frequently

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f , immunoblot analysis of AMPK in shCtrl and shGDH1 Huh7 cells in CHX chasing experiment
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MATLAB scripts and notebooks are available upon reasonable request from the corresponding authors