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The interplay between oxidative stress and diminished NO forms a vicious cycle, worsening hypertension [182, 185]

Studies have shown that TSA downregulates extracellular matrix (ECM) gene transcription and collagen expression in dermal fibroblasts by inhibiting the TGF-/Smad and MAPK/ERK signaling pathways, contributing to its antifibrotic effects (60,61)

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93 These findings illustrate the central role of exosomes in promoting stromal renewal through synchronized modulation of proliferative and anti-apoptotic signaling

In Vitro Effects of Curcumin on Proinflammatory Cytokines and Expression of Their Genes in Minor Salivary Gland Tissue of Patients with Sjogrens Syndrome. Rheumatology International, vol