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As a regulator of adipogenesis, PPAR activation negatively modulates mitochondrial HMGCS2 to govern intestinal cell differentiation (97)

Sandberg, GD

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The clinical manifestations of LCHAD deficiency result from direct toxicity of the build up of long-chain acyl-CoA esters causing cardiomyopathy and cardiac arrhythmias or from a block in long-chain fatty acid oxidation that leads to an inability to synthesize ketone bodies and/or adenosine triphosphate from long-chain fatty acids

11 Ksters-Vandevelde HV, Ksters B, van Engen-van Grunsven AC, Groenen PJ, Wesseling P, Blokx WA