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An AA rating indicates no known or suspected bioequivalence problems with conventional dosage forms

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Growth promoting actions of IGF-II is via the IGF1R and IGF1R-INSR hybrid receptors which has preference for IGF-II actions if the A isoform of the INSR receptor expressed in the fetus and in malignantly transformed cells - pairs with the IGF1R in the hybrid (106)
non-severe cases

Association between HO1 gene promoter polymorphisms and diseases (Review)
Oct 2001;86(10):4686-92
