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Footnotes AUTHOR CONTRIBUTIONS: G Liu and C Deng designed and guided the whole study and revised the manuscript

[PubMed 18334520] 3

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As the C-terminal domain is involved in regulating the subcellular localization of ArfGAP1 and its interaction with membranes (Yu and Roth, 2002), particularly via its ALPS 1 and 2 motifs, we asked whether the phospho-null and phospho-mimic variants adopt different localizations

This could contribute to liver diseases such as cirrhosis , which involves liver scarring and loss of function