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Ethics declarations Ethics approval and consent to participate Animal experiments in this study were approved by the Animal Ethics Committee of Razi University and followed with the Guidelines for the Care and Use of Laboratory Animals in Research (Animal Ethical Approval Number: IR.RAZI.REC.1402.027)

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A dedicated medication shelf or door pocket works well, as these areas maintain more stable temperatures than the freezer zone

* Correspondence: Kun Yang [email protected] Wenduo Liu [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

THIQ THIQ is a synthetic small molecule hMC4R agonist with moderate bioavailability (14%), rapid absorption (T max = 1hr) and a short T 1/2 (0.5hrs) [48]

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