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it has also been observed with many anticancer agents that were effective in rodent models but failed to demonstrate efficacy in human trials

Additional important metabolic regulatory enzymes that require flavin as a co-factor include, succinate dehydrogenase (TCA cycle and complex II of oxidative phosphorylation), glycerol-3-phosphate dehydrogenase (involved in the glycerol phosphate shuttle and triglyceride synthesis), and xanthine oxidase involved in purine nucleotide catabolism

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

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J., et al., Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers

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