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In tumors, hypoxia is triggered by the up-regulation of cell proliferation that increases the oxygen requirements, which subsequently cause neovascular formation and cellular adaptation through metabolic and enzymatic adjustment (47)

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Several expansive studies mapping the subcellular distribution of the human proteome have suggested that CHAC1 localizes to multiple organelles, including the mitochondria 45,46

Editor information Editors and Affiliations Rights and permissions Copyright information 2018 Springer Science+Business Media Singapore About this paper Cite this paper Dolbashid, A.S

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