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Food and Drug Administration (FDA) approved selumetinib (Koselugo ) for adults with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas

This condition is linked to the presence of an autoantibody targeting folate receptor alpha, the primary transporter of folate from the bloodstream to the brain and from mother to fetus

Lip-1, a spiroquinoxaline derivative, exhibits potent and selective inhibitory effects on iron-dependent lipid peroxidation pathways, making it a promising candidate for targeting ferroptosis

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