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Bhat AH, Dar KB, Anees S, Zargar MA, Masood A, Sofi MA, Ganie SA (2015) Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases

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VEGF-A and related family members have well-documented neuroprotective actions in the retinapromoting retinal ganglion cell survival, Mller-cell viability, and production of neurotrophic factors via VEGFR2 PI3KAkt signalingso prolonged suppression could, in principle, reduce endogenous neurotrophic support (Nishijima et al., 2007

[DOI] [PubMed] [Google Scholar] 120.Tennyson CA, Ciaccio EJ, Lewis SK

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To benchmark our approach against FI and established metabolomic clocks, we constructed comparator models that reflect key elements of prior frameworks trained on age 17 or untransformed metabolite levels 19 , though these models were developed on targeted NMR platforms and focused on age or mortality rather than health decline