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4.3 Acrolein as a modulator of stress-mediated gene activation Many transcription factors are regulated by redox-dependent mechanisms and utilize cysteine residues as ,redox switches. One toxicologically important example is the oxidative stress-sensing transcription factor, nuclear factor-B (NF-B)

The concept of using mRNA to stimulate cardiac repair after myocardial infarction (MI) has been explored for over a decade, and recent clinical trials are beginning to translate this approach to patients

For example, transferrin-conjugated nanoparticles utilize the overexpression of the transferrin receptor on cancer cells

doi: 10.1007/s11912-011-0202-z

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In the Diabetes Reduction Assessment with Ramipril and Rosiglitazone Medication (DREAM) research, rosiglitazone reduced T2DM and improved normoglycemia in IFG patients