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804 Lipid peroxide 4-HNE, which accumulates during myocardial I/R injury, promotes ubiquitination of GPX4 and induces cardiac ferroptosis by targeting the binding site of GPX4 and ovarian tumor deubiquitinase 5, while activation of aldehyde dehydrogenase 2 to degrade 4-HNE reduces myocardial ferroptosis

10.1097/MOL.0b013e32832fa58d 96 ItabeH.SawadaN.MakiyamaT.ObamaT

Shakeri S, Rafiee Z, Dashtian K (2020) Fe 3 O 4 -based melamine-rich covalent organic polymer for simultaneous removal of auramine O and Rhodamine B

That means you do not make methyl folate as best you should, which means your methylation capacity is likely down regulated

These are research pairings observed in the literature, not dosing recommendations

BMC Pharmacol Toxicol 22 , 31 (2021)