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Description
Riluzole (Rilutek) was approved for marketing by the FDA in 1995 [114] and is readily available worldwide [115]

G.JuangT.-Y.WangT.-F

M.MullanS

Ubiquitin is typically conjugated to lysine residues on substrate proteins, most classically via K48 linkages, forming polyubiquitin chains that are recognized by the 26S proteasome

Acknowledgments The manuscript was checked by Gulam Bahadur

Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer
