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To definitively establish causality, future research requires: (1) randomized trials of SSRI continuation versus discontinuation in older adults with remitted depression, with cognitive outcomes as co-primary endpoints

Over a follow-up period of 26.2 months, empagliflozin significantly reduced the composite risk of HFH or cardiovascular death by 21% (13.8% versus 17.1%

Data source FAERS database aggregates spontaneous adverse event (AE) reports from healthcare providers, manufacturers, and consumers 17

But the strength of a mechanistic argument does not override the need for careful clinical judgment, and both therapeutic approaches carry risk profiles that must be understood and managed individually

In addition to their clinical significance, Putrino believes the findings carry an urgent public health warning regarding blood donation