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This creates a cluster of overlapping symptoms, where Long COVID can trigger ME/CFS and exacerbate underlying mast cell and autonomic dysfunction, all fueled by a fundamental redox imbalance

Asmundson GJG, Paluszek MM, Landry CA, Rachor GS, McKay D, Taylor S (2020) Do pre-existing anxiety-related and mood disorders differentially impact COVID-19 stress responses and coping

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As a 26-year-old graduate student at Johns Hopkins in the early 1970s, Pert identified the opiate receptor the cellular binding site for the brain's own endorphins and then spent her career at the National Institute of Mental Health mapping how neuropeptides and their receptors form a signaling network linking brain, emotion, and immunity.3,4 She published more than 250 papers on peptides and receptors