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These trials include dedicated studies in patients with type 2 diabetes, allowing more precise characterization of glycemic benefits

95% CI, 0.22-0.36

A well-studied GIPR missense variant, E354Q (rs1800437), is associated with reduced BMI in large-scale GWAS and Mendelian randomization analyses

Mechanism Validation Concurrent data from Amgen's Vesalius-CV trial strengthened confidence in the PCSK9 mechanism, showing Repatha reduced cardiovascular death risk by 21% in high-risk patients without prior events

Micronutrient supplementation may be beneficial, though ideally guided by laboratory assessment rather than empiric supplementation

Of the 14,348 participants who attended visit 2, we excluded participants who were missing measurement of HbA 1c ( n =247), had a non-fasting blood draw ( n =197), had missing data for adjustment covariates ( n =88), had prevalent diabetes (glucose-lowering medication use, HbA 1c 6.5%, or FG 7.0 mmol/l) ( n =2401), had prevalent outcomes of interest ( n =1001) or were missing information on outcomes during follow-up ( n =47)