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In the MMR-D group (20% of the overall population), the 12-month PFS was 67.9%, HR 0.42 (95% CI 0.220.80), for the durvalumab arm, and the 12-month PFS was 70%, HR 0.41 (95% CI 0.210.75), for the durvalumab and olaparib arm compared to 43.3% in the control arm (Table 1)

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The correlation in our study was increased when T2DM patients concurrently developed CRC, indicating that sRAGE may be depleted with illness and concurrent disease progression and no longer have the capacity to trap additional AGEs

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