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Target validation: Comparison of target predictions with observations from previous literature As an initial validation, several of the genes in Table 1 were identified as proven drug targets in the literature and some have previously identified inhibitors in Leishmania or other related species

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Activation of AMP-activated protein kinase (AMPK) under energy stress conditions inhibits acetyl-CoA carboxylase (ACC), reducing fatty acid biosynthesis and limiting PUFA-PL incorporation into membranes

Biomolecules, 10 (9), 1202

Margolina, Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data, MDPI AG, Jul