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doi: 10.1016/j.braindev.2010.09.002

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In parallel, hepatocyte-directed PPAR gene therapy has been shown to enhance systemic -hydroxybutyrate availability, providing a neuroprotective energy substrate during cerebral metabolic crisis [128, 284, 285]

Under these criteria, subjects who agreed to levocarnitine supplementation with VPA treatment were enrolled consecutively and studied prospectively from September 2013 to June 2014 at Kusatsu Hospital in Hiroshima, Japan