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In the barrel-stave pore, the hydrophobic and hydrophilic arrangement of the lipids is maintained, whereas, in toroidal pores, the hydrophobic and hydrophilic arrangement of the bilayer is disrupted

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Sensorgram data were double referenced (subtraction of running buffer alone and flow cell 1) and fit to a 1:1 binding kinetics fitting model in Biacore evaluation software (Biacore Insight Evaluation Software Version 5.0.18.22102) to yield association and dissociation rate constants k on and k off , respectively

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The average increase in collagen density across all subjects was 28%