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Malek Mahdavi A, Mahdavi R, Kolahi S

Nov 2 2018;15(6):1010-1013

In contrast to the kidney, the liver has relatively less reserve pools of analytes to recover flux through these pathways, and thus energy production

This suggests that enzymatic activity of other UGTs involved in APAP metabolism UGT1A9, UGT1A6, and UGT2B15 - might compensate for deficiency in UGT1A1 function

We observed a clear correlation with the induction of NRF2 and CBS as examined by immunoblotting (Fig

The major limitation on this study is that the participants were treated on the basis of best available clinical therapy, not on a prospective clinical trial
