how long before b12 injection kicks in Does It Take for Shots to Work Fast? Why Do I Feel Worse

Press the plunger slowly and steadily until its fully down

This is followed by maintenance injections of 1mg every 2-3 months (or every 2 months with neurological involvement)

doi: 10.1074/jbc.M110.133579 64 MurphyMP

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If you accidently touch the needle, or it has contact with a non-sterile surface, use a new needle

Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized