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In mice and rats, three distinct GPx4 isoforms, cytosolic GPx4, mitochondrial GPx4 (mGPx4), and nuclear GPx4 (nGPx4), were identified with different functions

Determination of oxidative stress Pancreatic and liver levels of MDA, a marker of lipid peroxidation, were quantified using the method outlined by Uchiyama and Mihara [38]

Co-corresponding author and co-first author Fabio Hecht, PhD, and co-first author Marco Zocchi, PhD, led the study in the Harris lab in the Department of Biomedical Genetics

The body evolved during periods of food scarcity and interprets significant caloric reduction as famine

By reducing oxidative stress, glutathione lowers the risk of cancer development

Demir-Dora D, Ozsoy U, Yildirum Y, Yilmaz O, Aytac P, Yilmaz B, et al