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114 Prolonged exposure to alcohol leads to the release of oxidized mitochondrial DNA via extracellular vesicles in ALDH2-deficient mouse liver cells, and this DNA is transferred to nearby HCC cells and activates carcinogenic (JNK, STAT3, BCL2, and transcriptional coactivator with PDZ-binding motif) pathways, promoting the development of alcohol-related HCC
Bao L, Cai X, Zhang M, et al
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Nat Commun 10(1):244, 2019
The main mechanism of action of inflammatory response to DKD is shown in Figure 4
The N1IC_up gene signature was also significantly depleted by RSL3 treatment of TS543 neurospheres at both time points (Fig
