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Concurrent imaging data indicated that microglia play a predominant role in this process, suggesting that cortical plasticity occurs in the brains of FMS patients with FMS and is primarily mediated by microglial activation (127)

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doi: 10.3389/fnut.2024.1387802 Received 18 February 2024 Accepted 01 July 2024 Published 18 July 2024 Volume 11 - 2024 Edited by Adriana Ximenes-da-Silva, Federal University of Alagoas, Brazil Reviewed by Lanni Rocha, Federal University of Alagoas, Brazil Gary Landreth, Indiana University, United States Updates Copyright 2024 Zhang, Yang, Liu, Wang, Tan, Wang and Liu

In humans, the C-oxidation of nicotine to cotinine is the major pathway of nicotine metabolism and cotinine is used as a biomarker for nicotine exposure 40

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If the patients were given the highest dose (4.5 mg/week), 88% experienced side effects