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The SURMOUNT-1 trial demonstrated 20.9% mean body weight reduction with tirzepatide 15mg weekly at 72 weeks, while preclinical 5-amino-1MQ studies showed visceral fat reduction independent of caloric restriction
The MOTS-c 5-amino-1MQ stack protocol represents one of the most investigated combinations in cellular energy regulationpairing a mitochondrial-derived peptide with a nicotinamide N-methyltransferase (NNMT) inhibitor to target fat oxidation through two complementary pathways

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