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The therapeutic potential for GGC to increase GSH is related to the second GSH biosynthetic enzyme, glutathione synthetase (GS) which is not regulated by non-allosteric feedback inhibition by GSH

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One pathway creates NAPQIa reactive compound that needs to be neutralized quickly

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[PMC free article: PMC5451581] [PubMed: 28314764] 94

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H., Biebl, M

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This means decisions about supplementation remain largely based on mechanistic plausibility and practitioner experience rather than randomized controlled evidence

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Chemosphere, 375 , 144226

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