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Resmetirom is metabolized solely by CYP2C8 to a major disproportionate active metabolite in plasma, MGL-3623 (M1)

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7 Mitochondrial quality control and inflammation Mitochondrial quality control provides essential homeostatic functions including the regulation of the mitochondrial population to meet cellular energy demands, as well as the disposal of damaged mitochondria (Marchi et al., 2023)

The body treats prolonged stress as an oxidative event and antioxidant reserves take the hit