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The samples for hepatic metabolomics analysis were part of a larger metabolomics study of the plasma, kidney, heart, and lungdata from which have been reported 6,15

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doi: 10.1016/j.celrep.2014.04.045 9 MaddocksODBerkersCRMasonSMZhengLBlythKGottliebEet al

Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling

However, CHAC 1 shows activity that is approximately 20 times higher than that of CHAC 2

(2023) 9:e16206
