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Dysregulation of mitochondrial calcium (mtCa) uptake, particularly due to MICU1 deficiency, leads to progressive muscle weakness and atrophy in both patients and mouse models [293]

2012;345:e6698

Oxidative stress Oxidative stress, a concept introduced by Sies in 1985, arises when the endogenous antioxidant defense system of cells and tissues is unable to cope with a sudden or prolonged increase in ROS production, leading to the disruption of redox signaling and regulation, as well as molecular damage (Sies 1985, 2015

Effects of Citric Acid and l-Carnitine on Physical Fatigue

Pergola PE, Raskin P, Toto RD, Meyer CJ, Huff JW, Grossman EB, et al

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