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Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases, with patients bearing a high symptomatic burden and physical limitations that impact their daily lives

In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (, , )

Retrieved 19 April 2019

10.1006/mvre.2000.2288 329

Nanostructures find diverse applications in gene delivery, tissue engineering, drug delivery, biological labeling, protein tracing, pathogen detection, cancer therapy, DNA structure analysis, and serve as contrast agents in magnetic resonance imaging (MRI) and molecular sensing

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