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2019;37(1) Supplement 116:6369

In AD pathology, abnormally modified Tau proteins regulate microglial activation: Hyperphosphorylated Tau enters microglia via CX3CR1 receptor-mediated endocytosis, activating Syk tyrosine kinase signaling to induce phagolysosomal dysfunction and pro-inflammatory mediator release (36,37)

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Gating strategy (left) and quantifications (right) are shown ( n = 5)