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In addition, the promotion of HDAC1 to SMAD7 ubiquitination [92, 93], thereby decreasing the half-life of the protein, is also observed, although the concrete mechanism remains unknown

Translational efforts face an additional barrier: while CSF1R inhibitors allow experimental microglial manipulation, recreating their physiological complexityincluding precise spatial distribution and functional heterogeneitypresents a significant challenge for therapeutic development

Mumtaz S, Ali S, Qureshi MZ, Muhammad A, Manan A, Akbar Mughal T (2023) Antioxidant and anti-aging role of silk sericin in D-galactose induced mice model