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Activation of RAGE involves nuclear factor-B (NF-B) and its target genes, causing a shift from the to the isoform of myosin heavy chain in cardiac myocytes, which reduces myocardial contractility (46)

Jung C.H., Lee W.J., Hwang J.Y., et al

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Unlike the square-planar Pt () complex, the octahedral Pt () complex has two additional axial ligands, allowing adjustments to its biological properties like lipophilicity, selectivity, and redox stability

For example, studies in rat models of CKD showed that cognitive decline correlated with serum indoxyl sulfate levels and bloodbrain barrier (BBB) disruption