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A breakthrough in treatment is desperately needed otherwise the increasing patient numbers and associated treatment and care costs will severely impact our healthcare systems

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Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, et al

Though i n vitro experiments allow for easier control of mechanical and chemical stimulants, researchers still attempt to incorporate animal models to ensure that all aspects of the in vivo system are taken into account (146)