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Moreover, this condition could be further exacerbated in G6PD-deficient patients who are elderly, as increased age is correlated with reduced G6PD expression [14]

Together, GGT and ChaC1 regulate both intracellular and extracellular GSH degradation, emerging as promising prognostic markers and therapeutic targets for specific types of tumor such as liver cancer (172,173), breast cancer (74) and so on

Gerra G, Zaimovic A, Ampollini R, Giusti F, Delsignore R, Raggi MA, Laviola G, Macchia T, Brambilla F

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This in turn activates the JAK2/STAT3 pathway, promoting FAO and thereby driving M2 polarization while enhancing PD-L1-mediated T cell exhaustion (197)

Thus, the lncRNA IGF2-AS could represent a possible prognosis-related biomarker of CRC