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Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs

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Retatrutide is a triple agonist acting on GLP-1, GIP, and glucagon receptors, with phase 2 data published in the New England Journal of Medicine (2023) showing substantial weight reduction

This engineering approach demonstrates how protein-protein interactions can be selectively disrupted using stabilized peptide research tools, an approach that has informed peptide engineering more broadly

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