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Here, we show that Treg cells with a high energetic state display enhanced functional capacity

The primary mechanism identified for this analgesic effect was CAP's ability to increase transdermal agent transportation, thereby improving the efficacy of local anesthetics and reducing noxious stimulation (CHiCTR2000029063) [460]

Under hypoxic conditions, the stabilization of hypoxia-inducible factor-1 (HIF-1) occurs, a process heavily influenced by ROS

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At the protein level, LPP has been demonstrated to stimulate the expression of Sox9, aggrecan, and collagen II, with significant increases observed in Sox9 and aggrecan levels and in collagen II expression