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Conclusion It can be concluded that changes in antioxidant function, DNA damage, inflammation and a limited set of metabolic biomarkers (insulin and HDL cholesterol) may mediate improvements in cognitive function among older participants with MCI who practice Islamic Sunnah IF.

In effect, in order to exert its anti-mitochondrial dysfunction properties facilitating the synthesis of proteins, orotic acid has to be saltified with an organic cation eg, carnitine, for its total solubilization and subsequent ease of absorption

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